AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

A new study found that a gene recently recognized as a biomarker for Alzheimer's disease is actually a cause of it, due to its previously unknown secondary function that triggers a pathway that disrupts how cells in the brain turn genes on and off.

Cutting through the noise: A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use

As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal tr…

AI Uncovers New Cause of Alzheimer’s

Researchers have discovered that a gene previously seen as a biomarker for Alzheimer’s disease, PHGDH, actually plays a causal role by disrupting gene regulation in the brain. Using AI, the team revealed that PHGDH has a hidden DNA-binding function unrelated to its known enzymatic activity. This malfunction triggers early Alzheimer’s development, offering a new target for prevention.

AI Helps Unravel a Cause of Alzheimer’s Disease and Identify a Therapeutic Candidate

A new study found that a gene recently recognized as a biomarker for Alzheimer’s disease is actually a cause of it, due to its previously unknown secondary function that triggers a pathway that disrupts how cells in the brain turn genes on and off.