Manipulating a master regulator prevents tumor growth in mice

Manipulating a master regulator prevents tumor growth in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

Blocking a surprising master regulator of immunity eradicates liver tumors in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

A notorious performance-enhancing hormone helps tumors hide from the immune system

Blocking erythropoietin’s effects on macrophages fights cancer in mice

Blocking Erythropoietin Signaling in Mice Converts Liver Tumors into Immunotherapy Responders

Stanford University scientists have found that erythropoietin (EPO), a protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells also plays a surprising, critical role in dampening the immune system’s response to cancer. Their preclinical studies found that blocking activity of EPO converts formerly “cold” – or immune-resistant – liver tumors in mice into “hot” tumors teeming with cancer-fighting immun…