Geographic and age variations in mutational processes in colorectal cancer

Geographic and age variations in mutational processes in colorectal cancer

Colorectal cancer incidence rates vary geographically and have changed over time1. Notably, in the past two decades, the incidence of early-onset colorectal cancer, affecting individuals under the age of 50 years, has doubled in many countries2-5. The reasons for this increase are unknown. Here, we investigate whether mutational processes contribute to geographic and age-related differences by examining 981 colorectal cancer genomes from 11 coun…

Toxin produced by E. coli ‘could be driving bowel cancer rates in young people’

Scientists are trying to solve the puzzle of why rates of bowel cancer are rising among the under-50s worldwide. A toxin produced by E. coli may be driving rates of bowel cancer in young people, scientists have discovered. Experts believe the finding could help explain why rates of bowel cancer are rising among young people across the globe. The bacterial toxin – called colibactin – is capable of altering DNA and is produced by a strain of E. co…

Study: Childhood exposure to this bacteria could be driving rates of colorectal cancer in Millennials and Gen Xers

As rates of colorectal cancer soar in adults younger than 50—with the American Cancer Society reporting it to be the leading cause of cancer death among such men and the second leading among such women—scientists have been searching for the cause. Researchers might have just stumbled upon a potential answer to that without trying. A team of researchers led by the University of California San Diego has just identified the bacterial toxin colibact…

The alarm sounds louder and louder. Cases of colorectal cancer are skyrocketing in people under 50 years of age without knowing the causes, doubling in many countries in the last two decades. There are 30-year-olds, with no obvious risk factors or family history, who arrive at the hospital already with lethal metastases. A new study, led by computational biologist Marcos Díaz Gay (Santiago de Compostela, 33), suggests that behind this “epidemia”…

Bowel cancer in young people is on the rise. This toxin could be the cause

There are around 2,600 new bowel cancer cases in people aged 25-49 in the UK every year

TyG-BMI Index Predicts Colorectal Cancer Risk, Study Finds

A new analysis links higher triglyceride-glucose (TyG) and TyG–body mass index (TyG-BMI) levels to increased colorectal cancer (CRC) risk, especially among women, but not mortality.