New genetic clues uncovered in epilepsy drug resistance
- A new study in *eBioMedicine* revealed common genetic variants linked to drug resistance in epilepsy.
- Many individuals with epilepsy do not respond to antiseizure medications, leading to drug resistance.
- Researchers at UCL and UTHealth Houston examined genomes from 6,826 people, comparing drug-resistant cases to controlled ones.
- Professor Sisodiya stated the findings offer insights and genetic variants could be early biomarkers.
- Identifying genetic signatures early may predict drug resistance and improve personalized treatment for polygenic epilepsy.
16 Articles
16 Articles
How disturbed signaling pathways could promote epileptic seizures
Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy. In the affected areas, nerve cells and their layer structures are arranged in an atypical manner, which often makes drug therapy more difficult. A research team has now found evidence of profound changes in the dopamine system in FCD type 2.
Study: Cannabis-Based Medicines Improve Quality of Life in Patients With Treatment-Resistant Epilepsy
The Marijuana Herald - Marijuana news and information A new study published by the journal Brain and Behavior, and published online by the National Library of Medicine, found that cannabis-based medicinal products (CBMPs) may improve quality of life for individuals with treatment-resistant epilepsy. The study, conducted by researchers at Imperial College London and Kings College London, analyzed data from 134 patients enrolled in the UK Medical …
Optimal Frequency for Seizure Induction With Electroconvulsive Therapy and Magnetic Seizure Therapy in Nonhuman Primates
Electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) are effective in the treatment of medication-resistant depression. Determining the …
Absence Seizure: Symptoms, Causes, Diagnosis, Treatment, and Prevention
Absence seizure, formerly known as petit mal seizure, is a type of short seizure that usually causes a person to briefly lose focus, stare into space, and lose awareness of their surroundings. These seizures are often seen in children and typically last only a few seconds. The condition is a type of epilepsy , a condition that causes seizures. Seizures are caused by abnormal brain activity, in which a burst of uncontrolled electrical activity be…
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