Drug-Coated Balloon-Only Percutaneous Coronary Intervention in Acute Coronary Syndrome: Are We Sacrificing Individualized Pharmacotherapy for Simplicity?

Drug-Coated Balloon-Only Percutaneous Coronary Intervention in Acute Coronary Syndrome: Are We Sacrificing Individualized Pharmacotherapy for Simplicity?

Agreement: I AgreeBody: Dear Editor We read with interest the REC-CAGEFREE II trial evaluating stepwise DAPT de-escalation following DCB-only PCI in ACS patients [1]. Despite its clinical relevance, we believe several methodological and ethical concerns undermine the generalizability of its conclusions. Pharmacologically, the trial used various paclitaxel-coated balloons without subgroup stratification, introducing heterogeneity in drug delivery…