Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes

A new study involving Duke University (USA) reveals that changes in umbilical cord blood DNA could offer early clues about infants at higher risk of long-term health problems, such as diabetes, strokes, and liver disease, opening the door to earlier life-saving interventions.

Unravelling the Biology of Type 1 Diabetes by Mapping Early Genetics

Coupling genetics with circulating blood proteomics at birth can identify stable and infancy-specific protein quantitative trait loci (pQTL). Such early-life biomarkers might help uncover mechanistic insights for certain diseases. To use this approach to better understand the biology of type 1 diabetes (T1D), a German team constructed a genome-wide pQTL map of 1,985 proteins in 695 newborn babies (median age 2 days) at increased genetic risk of …

Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes

Scientists constructed a genome-wide protein quantitative trait loci map of 1985 proteins in 695 newborn babies at increased genetic risk of developing type 1 diabetes. [Nature Communications] Full Article