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Highly Efficient In Vivo Hematopoietic Stem Cell Transduction Using an Optimized Self-Complementary Adeno-Associated Virus

Summary by Stemwell Science News
Investigators used adeno-associated virus serotype 6 (AAV6) vectors and Cre recombination to systematically optimize the parameters for effective in vivo HSC transduction. They establishing an protocol that achieved functional recombination in over two-thirds of immunophenotypic HSCs. [Molecular Therapy-Methods & Clinical Development] AbstractFull ArticleGraphical Abstract
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Highly Efficient In Vivo Hematopoietic Stem Cell Transduction Using an Optimized Self-Complementary Adeno-Associated Virus

Investigators used adeno-associated virus serotype 6 (AAV6) vectors and Cre recombination to systematically optimize the parameters for effective in vivo HSC transduction. They establishing an protocol that achieved functional recombination in over two-thirds of immunophenotypic HSCs. [Molecular Therapy-Methods & Clinical Development] AbstractFull ArticleGraphical Abstract

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Stemwell Science News broke the news in on Friday, February 21, 2025.
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