Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants

Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants

N,N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenously. Despite growing interest in the experimental and therapeutic use of intravenous DMT, data are lacking on its clinical pharmacology. We conducted a double-blind, randomized, placebo-controlled crossover trial in 27 healthy participants to test different intravenous DMT administration regimens: plac…

How Māori People Are Reclaiming Psychedelic Mushroom Medicine

An Indigenous-led clinical trial in New Zealand is rekindling ancestral psychedelic practices for addiction and mental health treatment.