Laughing gas can potentially transform treatment for tough-to-beat depression

Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect

Nitrous oxide (N2O) induces rapid and durable antidepressant effects. The cellular and circuit mechanisms mediating this process are not known. Here we find that a single dose of inhaled N2O induces rapid and specific activation of layer V (L5) pyramidal neurons in the cingulate cortex of rodents exposed to chronic stress conditions. N2O-induced L5 activation rescues a stress-associated hypoactivity state, persists following exposure, and is nec…

Laughing gas appears to reduce depression, but researchers don't totally understand why

Nitrous oxide, better known as laughing gas, may offer a new way to treat people with major depression, if they haven't responded well to psychotherapy or antidepressants, a new Penn study shows. Researchers found it seems to stimulate certain neurons and activate brain circuits related to emotion and behavior.

Laughing gas can potentially transform treatment for tough-to-beat depression

Nitrous oxide-better known as "laughing gas"-can potentially transform treatment for tough-to-beat depression.

How Laughing Gas Revives Stressed Brain Circuits to Relieve Depression Fast

Depression that resists traditional treatments may have a surprising new contender: laughing gas. Researchers have discovered that nitrous oxide, commonly used as an anesthetic, can quickly lift mood and activate brain circuits dulled by stress, effects that may last long after the gas has left the body. By unlocking a novel brain mechanism involving specific [...]

One of the most common diseases in any country in the world and the worst one is certainly depression, something that affects many people on a daily basis and that leads to acts that they would not like to pass.This is often to prevent it from continuing to affect people who unfortunately have it, as we cannot forget that it is one of the most common diseases in many people depending on their situation.Obviously there are treatments for that, bu…

Laughing Gas: New Hope for Depression? – Archyde

Archyde Laughing Gas: Could This Old Anesthetic Be the Key to treating Severe Depression? New research suggests nitrous oxide offers rapid relief for treatment-resistant depression by targeting specific brain cells. A Surprising Turn for “Laughing Gas” in depression Treatment Nitrous oxide,the familiar “laughing gas” used for over a century in dental offices and operating rooms,may hold […] You can read the full story here: Laughing Gas: New Hop…