Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-199a-3p inhibits the MAPK4/NF-κB Signaling Pathway to Relieve Osteoarthritis

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (1…

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-199a-3p inhibits the MAPK4/NF-κB Signaling Pathway to Relieve Osteoarthritis

BACKGROUNDThere is currently no effective treatment for osteoarthritis (OA), which is the most common joint disorder leading to disability. Although human umbilical cord mesenchymal stem cells (hUC-MSCs) are promising OA treatments, their u