Hyper-Elevated RNA Polymerase II May Point to Increased Tumor Aggressiveness

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Hyper-Elevated RNA Polymerase II May Point to Increased Tumor Aggressiveness

Researchers from Fred Hutch Cancer Center and the University of Texas MD Anderson Cancer Center have used a new technique that directly measures gene transcription activity from DNA to show that hyper-elevated levels of RNA Polymerase II (RNAPII) are associated with tumor aggressiveness. The new technology—Cleavage Under Targeted Accessible Chromatin (CUTAC)—focuses on small, fragmented DNA noncoding sequences where RNAPII bind, located on the s…