IL-17A identified as a potential driver of cancer in familial adenomatous polyposis

New way to prevent duodenal cancer

People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP.

IL-17A identified as a potential driver of cancer in familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is a hereditary disease which, in addition to a high risk of bowel cancer, also a greatly increased risk of duodenal cancer.

Surge in immune cells may explain duodenal cancer risk in inherited disease

Familial adenomatous polyposis (FAP) is a hereditary disease which, in addition to carrying a high risk of bowel cancer, also greatly increases the risk of duodenal cancer. At present, the only treatment available is close endoscopic monitoring with removal of the precursors, known as polyps, although this is also associated with an increased risk.

Innovative Approach Unveiled to Prevent Duodenal Cancer

Familial adenomatous polyposis (FAP) stands as one of the most daunting hereditary disorders in the realm of gastrointestinal oncology, characterized primarily by the development of hundreds to thousands of polyps throughout the colon at an early age. Though the threat of colorectal cancer in FAP patients has been extensively studied, a subtler yet equally menacing risk lies in the duodenum—where neoplastic transformation occurs with alarming fr…