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Lung Immune Cell Type "Quietly" Controls Inflammation in COVID-19

  • A new study shows that nerve and airway-associated interstitial macrophages are crucial for survival from COVID-19 by controlling lung inflammation during infection with SARS-CoV-2.
  • Research led by NYU Langone Health found that mice lacking NAMs had heightened inflammation and failed to survive COVID-19 infection.
  • Experiments demonstrated that mice lacking NAMs had worsened inflammation and increased viral spread, resulting in their deaths.
  • Tests on lung tissue from intubated COVID-19 patients indicated decreased NAM activity in those who died, supporting the findings from mice studies.
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Lung Immune Cell Type "Quietly" Controls Inflammation in COVID-19

Findings promote "disease tolerance" approach instead of attacking the virus

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Medical Xpress broke the news in on Friday, April 25, 2025.
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