Metabolic syndrome is a big risk factor for early dementia, and what you do makes a difference, study suggests

Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease

Protective immunity, essential for brain maintenance and repair, may be compromised in Alzheimer’s disease (AD). Here, using high-dimensional single-cell mass cytometry, we find a unique immunometabolic signature in circulating CD4+ T cells preceding symptom onset in individuals with familial AD, featured by the elevation of CD38 expression. Using female 5xFAD mice, a mouse model of AD, we show that treatment with an antibody directed to CD38 le…

Dementia warning as four habits identified as worst for cognitive decline

Your behaviours at a younger age could affect your chances of experiencing cognitive decline in later life.

Metabolic syndrome in midlife linked to higher dementia risk

Having a larger waistline, high blood pressure and other risk factors that make up metabolic syndrome is associated with an increased risk of young-onset dementia, according to a study published on April 23, 2025, online in Neurology®, the medical journal of the American Academy of Neurology.

Young-Onset Dementia Risk Rises With Metabolic Syndrome

Vascular dementia and Alzheimer's incidence at younger ages also increased

Metabolic syndrome is a big risk factor for early dementia, and what you do makes a difference, study suggests

Metabolic syndrome is linked to greater risk of developing young-onset dementia, according to a new study. But there are preventive changes you can make today.

Metabolic syndrome linked to increased risk of young-onset dementia

Having a larger waistline, high blood pressure and other risk factors that make up metabolic syndrome is associated with an increased risk of young-onset dementia, according to a study published in Neurology.