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One of C. difficile's metabolic powers might be turning a toxin into a food

Summary by Drug Discovery and Development
Research from Vanderbilt University Medical Center, published in Cell Host & Microbe, sheds light on a unique survival tactic employed by Clostridioides difficile (C. diff), opening up potential avenues for therapeutic intervention against this major cause of healthcare-associated diarrhea and mortality. The study reveals that C. diff can use 4-thiouracil (4-TU), a compound found in the human gut… The post One of C. difficile’s metabolic powers …
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One of C. difficile's metabolic powers might be turning a toxin into a food

Research from Vanderbilt University Medical Center, published in Cell Host & Microbe, sheds light on a unique survival tactic employed by Clostridioides difficile (C. diff), opening up potential avenues for therapeutic intervention against this major cause of healthcare-associated diarrhea and mortality. The study reveals that C. diff can use 4-thiouracil (4-TU), a compound found in the human gut… The post One of C. difficile’s metabolic powers …

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Drug Discovery and Development broke the news in on Wednesday, March 26, 2025.
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