A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new University of Pittsburgh research published today in Nature Microbiology.

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United States

Self-destructing vaccine offers safer TB protection in monkeys

In order to stop the spread of multi-resistant tuberculosis strains, which are difficult to treat with drugs, WHO has emphasized the need to develop a new vaccine. And it is urgent, because tuberculosis is the most deadly infectious disease worldwide. Thus, only in 2022 it caused 1.3 million deaths. In 90% of infections, the immune system detects the bacillus of tuberculosis and controls it without producing disease. However, in 5-10% of those i…

Con el fin de frenar el avance de cepas de tuberculosis multirresistentes, de difícil tratamiento con fármacos, la OMS ha hecho hincapié en la necesidad de desarrollar una nueva vacuna.Y es urgente, porque la tuberculosis es la enfermedad infecciosa más mortífera a nivel mundial. Así, solo solo en 2022 causó 1,3 millones de muertes.En un 90% de las infecciones, el sistema inmunitario detecta el bacilo de la tuberculosis y lo controla sin produci…

Una vacuna autodestructiva ofrece mayor protección contra la tuberculosis en macacos

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Spain

A self-destructive vaccine provides greater protection against tuberculosis in macaques

According to statistics from the National Tuberculosis Control Program, each year Vietnam has 182,000 new cases of tuberculosis. However, only 57% of patients are diagnosed and treated, while 43% of people with the disease have not been detected in time.

Theo thống kê của Chương trình Chống lao quốc gia, mỗi năm Việt Nam có thêm 182.000 người mới mắc bệnh lao. Tuy nhiên chỉ có 57% bệnh nhân được chẩn đoán điều trị, còn 43% người mắc bệnh chưa được phát hiện kịp thời.

Người mắc bệnh lao vẫn còn bị kỳ thị, chưa được phát hiện kịp thời

TUOI TRE ONLINE

People with tuberculosis are still discriminated against and have not been detected in time.

A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new University of Pittsburgh research published in Nature Microbiology.

Medical Xpress

Self-destructing vaccine offers enhanced protection against tuberculosis in monkeys

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Ian Birkby

The in-built in protection mechanisms offer a safer and more effective way to combat the deadliest disease of 2024.

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Science Daily

Daniel Hogan

A new tuberculosis vaccine that self-destructs to enhance safety has shown promising results in macaque monkeys, providing better protection than traditional vaccines and eliminating the risks of vaccine-derived infections. A new study from the University of Pittsburgh, published today (January 10) in Nature Microbiology, reveals that a self-destructing vaccine given intravenously offers enhanced safety and [...]

Sci Tech Daily

Revolutionary TB Vaccine Protects, Then Safely Self-Destructs

Researchers headed by a team at Pitt University, in collaboration with scientists at Cornell University, have developed a self-destructing, intravenous (i.v.) Bacillus Calmette-Guérin (BCG) vaccine that in preclinical tests provided additional safety and protection against tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) in macaque monkeys. The in-built safety mechanism—a BCG “kill switch”—in the live, attenuated Mycobacterium bovis …

GEN - Genetic Engineering and Biotechnology News…

New, Safer, TB Vaccine with BCG "Kill Switch" Protects Mice and Monkeys

A novel vaccine strategy utilizing a self-destructing strain of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) has shown promising results in combating tuberculosis (TB) among macaque monkeys, according to a groundbreaking study conducted by researchers at the University of Pittsburgh. Published in the esteemed journal Nature Microbiology on January 10, 2025, this research uncovers the enhanced safety and protective efficacy provided by an i…

Self-destructing vaccine offers safer TB protection in monkeys

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