Preventing harmful protein aggregation: Synthetic peptides as the basis for multifunctional drugs in Parkinson's disease

Preventing harmful protein aggregation: Synthetic peptides as the basis for multifunctional drugs in Parkinson's disease

In Alzheimer's, Parkinson's, and type 2 diabetes, harmful protein aggregates and deposits, known as amyloid plaques, develop. There is also much evidence that these three diseases are interconnected and mutually reinforcing.

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

There are a group of diseases associated with protein misfolding and accumulation into amyloid fibers. Many of these diseases have a major impact on h…

Alzheimer's, Parkinson's, and type 2 diabetes cause harmful, sticky protein aggregates and deposits, known as amyloid plaques. There is also much evidence that these three diseases are interrelated and mutually reinforcing. A research team led by...

New AI tool may predict different structures of amyloid fibrils:...

A new artificial intelligence (AI) tool may help predict the structure of amyloid fibrils, that is, misfolded protein fibers that accumulate in the brain of people with neurodegenerative diseases such as Parkinson’s. Called Ribbonfold, the tool is designed to address the complex and variable structures of misfolded proteins by including “constraints” appropriate for detecting their ribbonlike features. “The ability to predict amyloid polymorphs …