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Protein S Genomics and Proteomics Refine Thrombosis Risk

Summary by JAMA Network
Protein S is a vitamin K–dependent protein named after Seattle, where it was isolated and characterized. Subsequently recognized as a multifunctional enzyme that plays a critical role in the regulation of coagulation, protein S limits excessive clot formation through its action on clot initiation and clot propagation. As a cofactor for tissue factor pathway inhibitor, protein S limits clot initiation by inactivating extrinsic factor Xa, and as a…

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JAMA Network broke the news in on Tuesday, April 22, 2025.
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