Pusan National University Researchers Develop Self-Protecting Nanoparticles for Effective Treatment of Colorectal Cancer

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Pusan National University Researchers Develop Self-Protecting Nanoparticles for Effective Treatment of Colorectal Cancer

Systemic circulation of chemotherapy drugs leads to off-target side effects, premature drug loss, and limited therapeutic efficiency in colorectal cancer (CRC) treatment. Researchers have now developed a drug delivery strategy in which CRC cell-activated nanoconjugates (CTNCs) are enclosed inside a pH-sensitive alginate matrix. This matrix provides a shield against the acidic environment of the stomach and small intestine, ensuring selective dru…