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Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19

Summary by Nature
The variable origins of persistent breathlessness after coronavirus disease 2019 (COVID-19) have hindered efforts to decipher the immunopathology of lung sequelae. Here we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that dif…

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Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19

The variable origins of persistent breathlessness after coronavirus disease 2019 (COVID-19) have hindered efforts to decipher the immunopathology of lung sequelae. Here we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that dif…

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Science in VancouverScience in Vancouver

Research at St. Paul’s Hospital Uncovers Cause of Lung Long COVID - Science in Vancouver

New research from the Centre for Heart Lung Innovation (HLI) at St. Paul’s Hospital has identified inflammation in the lungs’ smallest airways as the cause of pulmonary long COVID. A research team led by HLI Director, Dr. Don Sin, used xenon MRI, an advanced imaging technology, and single-cell sequencing of lung samples, supported by the HLI’s biobank team, to uncover the underlying mechanism behind persistent respiratory symptoms in long COVID …

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Science in Vancouver broke the news in on Friday, April 4, 2025.
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