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InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments

Summary by Nature
Mass spectrometry-based proteomics focuses on identifying the peptide that generates a tandem mass spectrum. Traditional methods rely on protein databases but are often limited or inapplicable in certain contexts. De novo peptide sequencing, which assigns peptide sequences to spectra without prior information, is valuable for diverse biological applications; however, owing to a lack of accuracy, it remains challenging to apply. Here we introduce…

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Science broke the news in on Monday, March 31, 2025.
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