Shared Breast Cancer and Aging Signatures Revealed by Single-Cell Mammary Tissue Atlas

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Shared Breast Cancer and Aging Signatures Revealed by Single-Cell Mammary Tissue Atlas

It is well known that aging brings an increased likelihood of developing cancer. What is not well understood are the cellular and molecular events that initiate the cancer. Now, researchers at the Jackson Laboratory (JAX) have created an atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development. The work investigates “how aging rewires transcriptomic …