US EditionSmall Molecule Blocks Mast Cell Receptor Behind Non-IgE Allergies
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Small Molecule Blocks Mast Cell Receptor Behind Non-IgE Allergies
Researchers at the University of Bonn, Germany, have shown that a receptor known as MAS-related G protein-coupled receptor-X2 (MRGPRX2) is a driver of type VII allergies, which are triggered by direct chemical stimulation rather than the classical immunoglobulin E (IgE)-dependent pathways. The team also developed a small-molecule MRGPRX2 agonist that blocks its activity called PSB-172656, which has the promise of being effective against hard-to-…
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