Editorial Expression of Concern: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Editorial Expression of Concern: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Ping pong chrysanthemum-like Bi-BiOI and ternary core–shell structured Pd@AuPt based dual-electric signal outputs biosensor for accurate detection of CA19 - 9

Carbohydrate antigen 19–9 (CA19 - 9) can be used as a biomarker for pancreatic cancer. Measuring the concentration of CA19 - 9 in serum i

Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer

The authors characterized PIKfyve, a lipid kinase that was integral to lysosomal functioning7, as a targetable vulnerability in PDAC. [Nature] Full Article

Targeting PIKfyve to Combat Pancreatic Cancer

Emerging research has unveiled a critical vulnerability in pancreatic ductal adenocarcinoma (PDAC), a notoriously aggressive cancer characterized by poor prognosis and limited treatment options. Scientists have identified that inhibiting PIKfyve, a lipid kinase involved in intracellular membrane dynamics, compels PDAC cells to engage a compensatory metabolic program centered on de novo lipid synthesis. This revelation not only advances our under…