Scientists identify critical enzymes for astrocytic GABA production in Alzheimer’s disease
- IBS researchers, led by C Justin Lee, identified SIRT2 as key in Alzheimer's memory loss.
- Reactive astrocytes produce excessive GABA due to amyloid plaques, causing cognitive decline.
- Molecular analysis, imaging, and electrophysiology helped identify SIRT2 and ALDH1A1 as critical enzymes.
- Mridula Bhalla stated inhibiting astrocytic SIRT2 in AD mice led to partial memory recovery and less GABA.
- Selective GABA inhibition, without affecting H2O2, allows studying their roles in Alzheimer's progression.
14 Articles
14 Articles


Scientists identify key enzyme in Alzheimer's disease that links brain inflammation to memory loss
A research team at the Institute for Basic Science (IBS) has identified a previously unknown enzyme, SIRT2, that plays a key role in memory loss associated with Alzheimer's disease (AD). The study, led by Director C Justin Lee, of the IBS Center for Cognition and Sociality, provides critical insights into how astrocytes contribute to cognitive decline by producing excessive amounts of the inhibitory neurotransmitter GABA.
Scientists identify critical enzymes for astrocytic GABA production in Alzheimer’s disease
A research team at the Institute for Basic Science (IBS) has identified a previously unknown enzyme, SIRT2, that plays a key role in memory loss associated with Alzheimer's disease (AD).
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Alzheimer’s detection with simple blood test
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