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Scientists identify critical enzymes for astrocytic GABA production in Alzheimer’s disease

  • IBS researchers, led by C Justin Lee, identified SIRT2 as key in Alzheimer's memory loss.
  • Reactive astrocytes produce excessive GABA due to amyloid plaques, causing cognitive decline.
  • Molecular analysis, imaging, and electrophysiology helped identify SIRT2 and ALDH1A1 as critical enzymes.
  • Mridula Bhalla stated inhibiting astrocytic SIRT2 in AD mice led to partial memory recovery and less GABA.
  • Selective GABA inhibition, without affecting H2O2, allows studying their roles in Alzheimer's progression.
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ramaonhealthcare.com broke the news in on Sunday, April 13, 2025.
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