Gene editing for immune cell therapies

Gene editing for immune cell therapies

Autologous T cells that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the B cell antigen CD19 have yielded remarkable clinical responses in patients with B cell malignancies, and are now on the market as anticancer ‘drugs’. Riding on this success, the field of immune cell engineering is rapidly growing, with creative solutions to major outstanding challenges, such as limitations in target antigen selection…

Empowering our immune system so that it is itself that attacks cancer. Immunotherapy has become in recent years the great asset of oncologists to advance the control of the disease. CAR-T therapies (Chimeric Antigen Recetor T-Cell), a type of immunotherapy that consists of extracting lymphocytes from the patient and instructing them in the laboratory through gene therapy so that, once reintroduced into the body, they are able to identify and att…

The Hospital Clínic de Barcelona leads a network of 13 centers throughout the state that have already treated 500 patients with advanced cancers through innovative CAR-T therapyThe CAR-T therapy achieves the complete remission of an incurable brain tumor in a 17-year-old patient The revolution in the fight against cancer that the advanced CAR-T therapies developed by public health already have a first official balance.

10 Revolutionary Things About CRISPR and Space Exploration

CRISPR, a powerful gene-editing technology, is redefining boundaries in biology and genetics. Simultaneously, space exploration continues to push human presence beyond Earth's atmosphere. When combined, CRISPR and space science hold immense potential in transforming how humans travel, live, and thrive in extraterrestrial environments. The implications are broad, ranging from biological resilience to planetary protection and long-term colonizatio…

The counselor, Rocío Hernández, shows that oncology patients who have been waiting for their test for more than a month "have dropped by 82%" thanks to, among other measures, "the hiring of an exclusive radiologist".

'Smart,' ultrasound-activated immune cells may soon provide long-lasting tumor destruction

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors—a smart fighter that destroys cancer cells for days without tiring. USC biomedical engineers have made this concept a reality, crafting what they have named the "EchoBack CAR T-cell," which could soon be a game-changer in the field of cancer immunotherapy.