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Experimental drug shown to slow multiple sclerosis disability

  • In 2025, the HERCULES trial studied tolebrutinib for non-relapsing SPMS across 31 countries.
  • Non-Relapsing SPMS lacks FDA-approved treatments, motivating the search for new therapies like tolebrutinib.
  • Researchers enrolled 1,131 patients aged 18-60, documenting prior disability progression and no recent relapses.
  • Tolebrutinib delayed disability progression by 31%; ALT elevations were observed in some tolebrutinib recipients.
  • Tolebrutinib may offer a new treatment for SPMS by impacting neuroinflammation, pending FDA review and monitoring.
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Cherokee Tribune Ledger NewsCherokee Tribune Ledger News
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Experimental Drug Can Slow MS Disability

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·Cherokee County, United States
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Medical Xpress broke the news in on Tuesday, April 8, 2025.
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