Experimental drug shown to slow multiple sclerosis disability
- In 2025, the HERCULES trial studied tolebrutinib for non-relapsing SPMS across 31 countries.
- Non-Relapsing SPMS lacks FDA-approved treatments, motivating the search for new therapies like tolebrutinib.
- Researchers enrolled 1,131 patients aged 18-60, documenting prior disability progression and no recent relapses.
- Tolebrutinib delayed disability progression by 31%; ALT elevations were observed in some tolebrutinib recipients.
- Tolebrutinib may offer a new treatment for SPMS by impacting neuroinflammation, pending FDA review and monitoring.
38 Articles
38 Articles

Experimental Drug Can Slow MS Disability
Key Takeaways
Tolebrutinib shows promise for treating non-relapsing secondary progressive multiple sclerosis
A Cleveland Clinic-led clinical trial of tolebrutinib, an investigational oral Bruton's tyrosine kinase inhibitor, a group of drugs originally developed to treat lymphomas and related blood disorders, demonstrated a 31% delay in the onset of six-month confirmed disability progression (CDP) in patients with non-relapsing secondary progressive multiple sclerosis (SPMS).
Trial is the first to show a delay in confirmed disability progression in non-relapsing secondary progressive MS
A Cleveland Clinic-led clinical trial of tolebrutinib, an investigational oral Bruton's tyrosine kinase inhibitor, a group of drugs originally developed to treat lymphomas and related blood disorders, demonstrated a 31% delay in the onset of six-month confirmed disability progression (CDP) in patients with non-relapsing secondary progressive multiple sclerosis (SPMS).
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