City of Hope researchers uncover the two-step process of tumor formation

Tumor formation's two-step process: Mutated cells can persist for long periods without turning cancerous

Researchers at City of Hope have found that cell mutations are necessary but not always sufficient for tumors to form. Instead, they suggest that additional risk factors that promote tumor growth, like chronic inflammation, are a key trigger for tumor formation.

City of Hope researchers uncover the two-step process of tumor formation

Researchers at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, have found that cell mutations are necessary but not always sufficient for tumors to form.

City of Hope-Led Study Demystifies Tumor Formation’s Two-Step Process — A Foundational Understanding Needed to Prevent Cancer

Preclinical data showed that mutated cells can persist for years without becoming cancer and require additional inflammatory push for malignancy to occur.