Immune Checkpoint Inhibition Perturbs Neuro-immune Homeostasis and Impairs Cognitive Function

Tyrosine Kinase and PD-1 Inhibitors Boost Liver Cancer Treatment

In a groundbreaking study poised to reshape therapeutic strategies for hepatocellular carcinoma (HCC), researchers have demonstrated the superior efficacy and safety of combining tyrosine kinase inhibitors (TKIs) and programmed cell death protein-1 (PD-1) inhibitors with hepatic arterial infusion chemotherapy (HAIC) or transarterial chemoembolization (TACE) in managing recurrent unresectable HCC. This advancement offers renewed hope for patients…

Immune Checkpoint Inhibition Perturbs Neuro-immune Homeostasis and Impairs Cognitive Function

Background. Blockade of Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) significantly improves progression-free survival of individuals with cancers, including melanoma. In addition to unleashing antitumor immunity, immune checkp...